Heung-Min Son returns to the Tottenham starting XI for the first time this season after completing a three-match ban.
The midfielder was shown a red card in the defeat to Bournemouth back in May and missed the final game of the 2018/19 season, as well as the opening two matches of this campaign against Aston Villa and Manchester City.
Club-record signing Tanguy Ndombele has been ruled out after sustaining a minor injury during training this past week.
Dele Alli has returned to first-team training for Spurs having recovered from a hamstring problem, but the match against Steve Bruce’s side comes too soon.
Allan Saint-Maximin makes his first start for Newcastle since his summer move from Saint-Etienne, but DeAndre Yedlin and Andy Carroll remain sidelined.
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Tottenham: Lloris, Walker-Peters, Alderweireld, Sanchez, Rose, Winks, Sissoko, Lamela, Moura, Son, Kane
Subs: Gazzaniga, Vertonghen, Dier, Lo Celso, Eriksen, Skipp, Davies
Newcastle: Dubravka, Krafth, Schar, Lascelles, Dummett, Hayden, Longstaff, Almiron, Saint-Maximin, Ritchie, Joelinton
Subs: Darlow, Shelvey, Muto, Willems, Fernandez, Manquillo, Atsu
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