Ole Gunnar Solskjaer has made five changes to his team as Manchester United host West Ham, live on talkSPORT.
Marcos Rojo, Phil Jones, Juan Mata, Jesse Lingard and Anthony Martial come in for Victor Lindelof, Ashley Young, Luke Shaw and Scott McTominay.
Solskjaer has given a first start to Rojo, who is likely to deputise at left-back in the absence of suspended pair Young and Shaw.
Meanwhile, Lingard and Martial are deemed fit enough to start.
Paul Pogba will be hoping to get back on the scoresheet after going eight games without a goal.
Meanwhile, West Ham boss Manuel Pellegrini has made three changes to his team.
Pablo Zabaletam, Arthur Masuaku and Robert Snodgrass replace the ill Marko Arnautovic, Aaron Cresswell and Ryan Fredericks.
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West Ham won 3-1 against United at the London Stadium in September thanks to strikes from Arnautovic, Felipe Anderson and a Lindelof own goal.
Manchester United: De Gea, Dalot, Smalling, Jones, Rojo, Fred, Pogba, Mata, Lingard, Martial, Lukaku
Subs: Romero, Darmian, Lindelof, Pereira, McTominay, Greenwood, Rashford
West Ham: Fabianski, Zabaleta, Balbuena, Ogbonna, Masuaku, Rice, Noble, Snodgrass, Lanzini, Anderson, Hernandez
Subs: Adrian, Obiang, Diop, Fredericks, Antonio, Diangana, Holland