Aaron Ramsey has overcome injury to start Arsenal’s clash with Newcastle – but there is no place in the starting XI for top scorer Pierre-Emerick Aubameyang.
Granit Xhaka misses out completely, failing to recover from a knock picked up on international duty, while Nacho Monreal has shaken off a minor injury to start at the Emirates.
Arsenal, who are without the suspended Lucas Torreira, can overtake bitter north London rivals Tottenham in third if they get a point against the Magpies.
Spurs suffered yet another away defeat on Sunday, losing 2-1 to Liverpool courtesy of an unfortunate 90th minute own goal from Toby Alderweireld.
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Meanwhile, Newcastle captain Jamaal Lascelles starts after he missed the 2-2 draw at Bournemouth due to a knee problem.
Fabian Schar misses out through suspension, but would almost certainly have sat out anyway after being knocked unconscious in a clash of heads during Switzerland’s 2-0 Euro 2020 qualifying win over Georgia last Saturday.
The Magpies will be looking to move further away from the relegation zone, with eight points currently separating them from Cardiff.
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Here are the teams in full:
Arsenal: Leno, Mustafi, Papastathopoulos, Monreal, Maitland-Niles, Ramsey, Guendouzi, Kolasinac, Ozil, Iwobi, Lacazette.
Subs: Cech, Elneny, Mkhitaryan, Aubameyang, Suarez, Jenkinson, Nketiah.
Newcastle: Dubravka, Yedlin, Lascelles, Lejeune, Dummett, Ritchie, Hayden, Diame, Almiron, Perez, Rondon.
Subs: Darlow, Manquillo, Fernandez, Kenedy, Ki, Shelvey, Muto.